![]() Their next step is to investigate mechanisms causing this. “Moreover, heart muscle cells have their own natural immune machinery too.” However, it’s apparently possible this response could also damage the heart muscle and even kill cells. “Host natural immunity is the first line of defense against pathogen invasion,” the lead study author explains. Ivermectin, hydroxychloroquine, and chloroquine are especially important in preventing new binding of the spike protein to the ACE2 receptors that need to be bound in order for either the spike protein alone or for the entire virus to gain entry into the target cells ( Lehrer and Rheinstein, 2020 Wang et al., 2020 Eweas et al., 2021). ![]() It first engages its host’s receptor ACE2 enzyme, and then attempts to invade via this route. What we do know is the COVID-19 virus enters healthy cells using the spike protein on its surface. That’s why it’s important to get vaccinated and prevent this disease,” he told Medical News Today on August 1, 2021. Interestingly, the team found that antibodies blocking CD147 - a receptor for the spike protein protected heart pericytes from damage. Our data show that the spike protein from SARS-CoV-2 causes heart muscle damage. The spike protein made pericytes unable to interact with their companion endothelial cells and induced them to secrete inflammatory cytokines, suggesting the spike protein is harmful to human cardiac cells. “What we suspect is that the spike protein has unknown pathological roles. “However, what we don’t know is the mechanistic details of how this occurs. “It’s already known from the clinical side that COVID-19 infection can induce heart injury, the lead study author explains. Therefore they hoped to understand this better in the search for new treatments promoting cardiac health.īut their keynote finding was the spike protein could inflame the heart muscle leading to heart injury. Moreover, other research confirms patients who shelter at home are also at increased risk of cardiovascular conditions. The Utica researchers investigated other findings that up to 62% of hospital patients with COVID-19 experienced cardiac injury. Could a viral protein spike your heart in that sense? Could the Viral Spike Protein Harm Your Heart? Medical News Today explains the spike protein could provide that route. The implications of this finding are unclear, since it is yet unknown how the spike protein evades cleavage or clearance, especially in the setting of a normal. The found the virus damages heart muscle in an inflammatory pathway independent of ACE-2 receptors. Patients who developed postvaccine myocarditis had persistently elevated free spike protein in circulation, which correlated with evidence of cardiac injury and inflammatory cytokines. linked to Masonic Medical Research Institute in Utica, New York investigated the link between COVID-19 and heart disease. Hence, there are even more reasons to intervene with the use of anti-oxidant compounds, such as luteolin, in addition to available vaccines and anti-inflammatory drugs to prevent the harmful actions of the spike protein.ĪCE2 antibodies blood vessels blood-brain barrier coronavirus endothelial cells receptor spike protein.Ĭopyright 2021 Biolife Sas. In this regard, it is known that polyphenols are natural anti-oxidants with multiple health effects. In COVID-19, a response to oxidative stress is required by increasing anti-oxidant enzymes. These findings may be even more relevant to the pathogenesis of long-COVID syndrome that may affect as many as 50% of those infected with SARS-CoV-2. One paper reported that certain antibodies in the blood of infected patients appear to change the shape of the spike protein so as to make it more likely to bind to cells, while other papers showed that the spike protein by itself (without being part of the corona virus) can damage endothelial cells and disrupt the blood-brain barrier. ![]() However, recent reports have raised some skepticism as to the biologic actions of the spike protein and the types of antibodies produced. The best well-known vaccines have utilized either mRNA or an adenovirus vector to direct human cells to produce the spike protein against which the body produces mostly neutralizing antibodies. The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. ![]() The COVID-19 pandemic necessitated the rapid production of vaccines aimed at the production of neutralizing antibodies against the COVID-19 spike protein required for the corona virus binding to target cells. ![]()
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